منابع مشابه
Complement Activation in Placental Malaria
Sixty percent of all pregnancies worldwide occur in malaria endemic regions. Pregnant women are at greater risk of malaria infection than their non-pregnant counterparts and have a higher risk of adverse birth outcomes including low birth weight resulting from intrauterine growth restriction and/or preterm birth. The complement system plays an essential role in placental and fetal development a...
متن کاملComplement activation, placental malaria infection, and birth weight in areas characterized by unstable malaria transmission in central Sudan
BACKGROUND The pathogenesis of malaria during pregnancy is not completely understood. There are few published data on complement activation and malaria during pregnancy. This study aimed to investigate complement activation and malaria during pregnancy, and their association with hemoglobin and birth weight. METHODS A cross-sectional study was conducted at Medani, Sudan. Soluble terminal comp...
متن کاملImpaired placental autophagy in placental malaria
BACKGROUND Placental malaria is a major cause of low birthweight, principally due to impaired fetal growth. Intervillositis, a local inflammatory response to placental malaria, is central to the pathogenesis of poor fetal growth as it impairs transplacental amino acid transport. Given the link between inflammation and autophagy, we investigated whether placental malaria-associated intervillosit...
متن کاملDiagnosis of placental malaria.
In a group of 596 delivering Ghanaian women, the sensitivities of peripheral blood thick film microscopy, ICT Malaria P.f/P.v test, and PCR in detecting microscopically confirmed placental Plasmodium falciparum infection were 42, 80, and 97%, respectively. In addition to the gross underestimation of placental malaria by peripheral blood film microscopy, submicroscopic infections were found to b...
متن کاملGrading schemes for placental malaria.
To the Editor—We have read with great interest the article by Muehlenbachs et al [1], in which the authors present a histological grading scheme for placental malaria. The authors emphasize that the basic aim of the proposal is to provide a tool to improve the comparison and standardization between the studies conducted in different geographical areas. However, it is surprising that the presenc...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2015
ISSN: 1664-302X
DOI: 10.3389/fmicb.2015.01460